Nonaka Usaien: A Living Legacy of Edo-Period Pharmaceutical Heritage on the Nagasaki Kaido

Standing proudly along the historic Nagasaki Kaido highway in the Zaimoku district of Saga City, the Nonaka Usaien building is a rare and remarkable survival of Edo-period commercial architecture. Registered as a national Tangible Cultural Property since the year 2000, this two-story wooden structure has served as the home and workshop of the Nonaka family's celebrated herbal medicine business for over two centuries. The building's striking plastered facade, grand central gable, and traditional signboard frame evoke the prosperous merchant culture that once thrived along one of Japan's most important historical highways.

Historical Background

The origins of Nonaka Usaien trace back to the late 18th century, when the first generation of the Nonaka family, Genbei, established their pharmaceutical business in 1791 (Kansei 3). The family's fortunes rose dramatically in 1796 (Kansei 8), when the fourth head of the family, Nonaka Chubei, was granted exclusive manufacturing and sales rights for the herbal medicine known as "Usaien" by the Nabeshima clan, the feudal lords of the Saga Domain. It is believed that the current building was constructed around this time to serve as both a shop and residence.

The medicine "Usaien" itself has roots that reach far deeper into history. Its formulation originates from the Chinese pharmacopoeia "Taiping Huimin Hejiju Fang" (Prescriptions of the Pharmacy of Benevolent Aid), a renowned Song Dynasty medical text. The preparation is a nourishing tonic made from a blend of natural herbal ingredients—including ginseng, Angelica root, Cnidium rhizome, and ox bezoar—bound together with honey. It was historically reputed to have been favored by the Tokugawa shogunate, adding to its prestige.

The building's oldest sections are the shop area and the parlor known as "Reizenro." An inscription titled "Reizenro Meiki" that hangs within the parlor bears a postscript dated to 1820 (Bunsei 3), confirming that these sections were constructed before that year. Additional wings were added during the early Showa period around 1928, expanding the structure to its current configuration. In 1867 (Keio 3), the ninth-generation head, Nonaka Motouemon, participated in the Paris World Exposition as an envoy of the Saga Domain, where the Usaien medicine was exhibited to an international audience.

Designation as a Registered Tangible Cultural Property

Nonaka Usaien was registered as a national Tangible Cultural Property (building) on February 15, 2000. The designation recognizes the building's significance on multiple grounds. Its broad plastered walls facing the street, the prominent central gable over the entrance, and the distinctive frame used for hanging the shop sign all preserve the atmosphere of an Edo-period merchant house in excellent condition. As one of the best-preserved examples of a grand commercial building in the Saga area, the structure makes an invaluable contribution to the historical landscape along the Nagasaki Kaido and the surrounding townscape. The efforts of the Nonaka family to maintain and preserve the building through successive generations have been highly commended.

Architectural and Cultural Highlights

The Nonaka Usaien building is a two-story wooden structure with a traditional tile roof, covering a generous floor area of approximately 363 square meters. The facade extends broadly along the street, presenting an imposing presence that immediately draws the eye. At its center, a large decorative gable rises above the entrance, a hallmark of prosperous Edo-period merchant establishments. The traditional signboard frame, or yagura, from which the shop's signage was displayed, adds to the building's distinctive character.

The interior preserves elements of different historical periods. The Reizenro parlor, with its refined tatami rooms, reflects the aesthetic sensibilities of the late Edo period. The adjoining shop area retains the functional layout of a traditional apothecary, where generations of the Nonaka family prepared and sold their renowned medicines. The Showa-era additions blend harmoniously with the original structure, demonstrating how the building adapted over time while maintaining its essential character.

Today, the successor company Usaien Pharmaceutical Co., Ltd. continues to operate from the premises, manufacturing health supplements and medicinal products that carry forward the Nonaka Usaien tradition. The building also holds a blue-celadon statue of Shennong, the legendary Chinese god of medicine and agriculture, which the family has venerated for generations—a testament to the deep connection between the Nonaka family and the history of Asian pharmaceutical traditions.

Visitor Information

Nonaka Usaien is located at 1-82 Zaimoku, Saga City, Saga Prefecture. As the building remains a working business premises, interior viewing may be limited. However, the impressive exterior can be appreciated from the street at any time. The building is particularly noteworthy during the annual Saga Castle Town Hina Matsuri festival (mid-February to mid-March), when the Nonaka family's collection of heirloom hina dolls, passed down through generations since the Edo period, is displayed inside the building.

The nearest bus stop is "Gofukumotomachi," accessible from JR Saga Station Bus Center by Saga City Bus or Nishitetsu Bus. The walk from Saga Station takes approximately 20 minutes. If arriving by car, the Saga-Yamato Interchange on the Nagasaki Expressway is about 30 minutes away, and free parking is available at the nearby Saga City Historical Folk Museum.

Surrounding Attractions

Nonaka Usaien is situated within one of the richest concentrations of historical architecture in Saga City. The nearby Saga City Historical Folk Museum (Saga-shi Rekishi Minzoku-kan) comprises seven beautifully preserved buildings from the Meiji and Taisho periods, all open to the public free of charge. These include the former Koga Bank, a striking Western-style building from 1906 that now houses the Romanza café; the former Koga Residence, a Meiji-era banker's home; and the former Ushijima Residence, the oldest surviving townhouse from the Saga castle town.

A short walk along the Nagasaki Kaido leads to additional points of interest, including the Hizen Tosen-tei tea house, which introduces the history of sencha green tea culture in Saga, and the Nanri-tei, a renovated historical residence. The Saga Castle History Museum, located within the reconstructed main hall of Saga Castle, offers free admission and provides an excellent overview of the region's history. Saga City is also well known for its abundance of Ebisu (god of fortune) stone statues scattered throughout the streets, making for a delightful treasure hunt while exploring the area.

📍 Plan Your Visit to Saga
Find tours, activities & transport passes near Nonaka Karasaien
[ Yoshinogari Ruins & Arita Pottery Workshop Tours ]

Q&A

QWhat is the medicine "Usaien" and is it still available today?
AUsaien is a traditional herbal tonic made from natural ingredients including ginseng, Angelica root, and ox bezoar, blended with honey. It has been used as a nourishing supplement for fatigue, digestive weakness, and general vitality. The successor company, Usaien Pharmaceutical Co., Ltd., continues to manufacture and sell the medicine as a registered third-class pharmaceutical product in Japan.
QCan visitors go inside the Nonaka Usaien building?
AAs the building is a working business premises for Usaien Pharmaceutical Co., Ltd., regular interior tours are not available. However, the impressive exterior can be viewed from the street at any time. During the annual Saga Castle Town Hina Matsuri festival (mid-February to mid-March), the interior is sometimes opened to display heirloom hina dolls.
QWhat is the Nagasaki Kaido and why is it historically significant?
AThe Nagasaki Kaido was one of Japan's most important highways during the Edo period, connecting Kokura (present-day Kitakyushu) to Nagasaki across approximately 228 kilometers. As the sole route to Japan's only open trading port during the era of national isolation, it carried feudal lords, Dutch and Chinese traders, and Western knowledge into the heart of Japan. The road passed through Saga, making it a thriving commercial hub.
QHow do I get to Nonaka Usaien from Saga Station?
AFrom JR Saga Station, you can take a bus from the Saga Station Bus Center toward Saga University or Nishiyoka direction and alight at the "Gofukumotomachi" bus stop. From there, it is about a one-minute walk. Alternatively, the walk from Saga Station takes approximately 20 minutes heading south through the city center.
QWhat other historical sites can I visit in the area?
AThe surrounding Yanagimachi district is home to the Saga City Historical Folk Museum, a collection of seven preserved Meiji and Taisho-era buildings open free of charge. Nearby, you can also visit the Saga Castle History Museum (free admission), the Hizen Tosen-tei tea house, and explore the many Ebisu stone statues scattered throughout the old castle town streets.

Basic Information

Name Nonaka Usaien (野中烏犀圓)
Cultural Property Designation Registered Tangible Cultural Property (Building)
Registration Date February 15, 2000
Construction Circa 1796 (Kansei 8); additions in 1928 (Showa 3)
Structure Two-story wooden building, tile roof, approximately 363 m²
Address 1-82 Zaimoku, Saga City, Saga Prefecture 840-0055
Owner / Operator Usaien Pharmaceutical Co., Ltd.
Business Hours 8:00–17:00 (closed Saturdays, Sundays, and public holidays)
Phone 0952-23-2065
Access Bus stop "Gofukumotomachi" (approx. 1 min walk); approx. 20 min walk from JR Saga Station

References

野中烏犀圓 - 文化遺産オンライン
https://bunka.nii.ac.jp/heritages/detail/137308
国指定文化財等データベース(文化庁)
https://kunishitei.bunka.go.jp/bsys/maindetails/101/00001538
野中烏犀圓 - さがの歴史・文化お宝帳
https://www.saga-otakara.jp/search/detail.html?cultureId=5360
野中ウサイエン - 佐賀市公式ホームページ
https://www.city.saga.lg.jp/main/4883.html
ウサイエン製薬株式会社 公式サイト
https://usaien.com/about/
ウサイエン製薬(株) - 佐賀市観光協会公式ポータルサイト
https://www.sagabai.com/main/?cont=kanko&fid=458

Last verified: 2026.04.13